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In vitro Profiling of Indian Patients Head & Neck Tumor Derived Spheres

Head and Neck (H&N) cancers are malignant types contributing to one-third of all cancer types in India. The actual burden of this cancer type in India is much greater than reported and reflected through the existing literature. South-East Asia is documented to face steep increase of over 75% in the number of cancer deaths in 2020 as compared to 2000. Also, on the logic of Indian population becoming nearly twice that of the world in the past 15 years, increase in cancer burden with the same proportion is anticipated.

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Rethinking Drug Discovery

The quest to undertake biological targets that are based on the regulation of signalling pathways is challenging the classical thinking in the drug discovery arena. Historically, the complexity of the biological system was underestimated! It is now well-accepted that compared to old biological targets that were focused on single gene or gene products, we need to undertake targets that are derived from complex and dynamic signalling pathways.

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Integrated Treatment Regime for Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD), a genetic neuromuscular disorder, has a pernicious influence on skeletal and cardiac muscle tissue and results in a significant decline in the life span of those affected. The destruction is mainly attributed to perpetuating inflammation and fibrosis.

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Stem Cell – Implant Composites for Periodontal Tissue Revival

Owing to good biocompatibilities, resistance to corrosion and mechanical properties, Titanium (Ti) implants are popularly used in dentistry. The fundamental aspect in the performance of an implant is the mechanical and biological behaviour of its interface with the surrounding micro-environment of the periodontium. A stable, tissue friendly biological and not inert interface between the biomaterial surface and the surrounding tissue is a vital prerequisite both for immediate implant loading and for the long-term success of such implants.

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Laser Irradiation on Human Umbilical Cord Stroma Derived Mesenchymal Stem Cells for Regenerative Medicine Applications In vitro Study

Mesenchymal Stem Cells (MSCs) were exposed to single dose of laser irradiation and cellular properties were assessed by Trypan Blue Method, MTT assay, surface marker analysis, LDH secretion and genomic integrity assays. This investigation revealed that the stem cell culture characteristics were retained post irradiation with documented increase in the yield of cultured cells in less time. The authors speculate that the laser irradiation on cultured clinical grade cells aid in packaging these cells for regenerative therapeutic applications.

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